An Overview of Rheumatoid Arthritis

Rheumatoid Arthritis Symptoms and Signs

The main symptom of rheumatoid arthritis is joint stiffness in the morning, often in the hands or feet. Stiffness that persists for an hour or more, or swelling and pain that lasts for more than six weeks, may be indicative of rheumatoid arthritis. Joint discomfort is typically symmetrical, i.e. both hands will hurt or feel stiff, not just one. Early rheumatoid arthritis symptoms also may include fever, excessive tiredness, or pea-sized lumps called "nodules" that can be felt under the skin.

Other possible rheumatoid arthritis symptoms include anemia, appetite loss, and the accumulation of fluid in the ankles or behind the knee. In children, symptoms may include shaking chills and a pink rash may follow the characteristic painful and swollen joints.

Why Rheumatoid Arthritis Is Painful

How joint pain and the destruction of cartilage are related is not fully understood. Cartilage itself does not cause pain because there are no nerve structures in cartilage to transmit pain signals. Most likely, the pain of rheumatoid arthritis is caused by the irritation of other tissues in and around the affected joints. This irritation may be caused by chemical-messenger substances, such as prostaglandin E2, that are associated with the disease process. Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce pain because they inhibit the production of prostaglandins.

Other Conditions That Can Cause Pain

Pain and stiffness similar to rheumatoid arthritis symptoms can be caused by many other conditions. Even if injury or infection can be ruled out, anything from bunions to fibromyalgia or chronic fatigue syndrome can cause pain.

Only a medical professional can identify many sources of joint pain, because similar symptoms can result from other autoimmune diseases, from serious conditions such as cancer, or from many other kinds of arthritis.

Types of Arthritis

There are more than 100 different types of arthritis. Some of the more common types include:

Osteoarthritis.

This is the most common type of arthritis. It occurs when the cartilage covering the end of the bones gradually wears away. Without the protection of the cartilage, the bones begin to rub against each other and the resulting friction leads to pain and swelling. Osteoarthritis can occur in any joint, but most often affects the hands and weight-bearing joints such as the knee, hip and facet joints (in the spine). Osteoarthritis often occurs as the cartilage breaks down, or degenerates, with age. For this reason, osteoarthritis is sometimes called degenerative joint disease.

Rheumatoid arthritis.

Rheumatoid arthritis is a long-lasting disease that can affect joints in any part of the body but most commonly the hands, wrists, and knees. With rheumatoid arthritis, the immune system -- the body's defense system against disease -- mistakenly attacks itself and causes the joint lining to swell. The inflammation then spreads to the surrounding tissues, and can eventually damage cartilage and bone. In more severe cases, rheumatoid arthritis can affect other areas of the body, such as the skin, eyes, and nerves.

Gout.

Gout is a painful condition that occurs when the body cannot eliminate a natural substance called uric acid. The excess uric acid forms needle-like crystals in the joints that cause swelling and severe pain. Gout most often affects the big toe, knee and wrist joints.

What is arthritis?

Arthritis is a joint disorder featuring inflammation. A joint is an area of the body where two different bones meet. A joint functions to move the body parts connected by its bones. Arthritis literally means inflammation of one or more joints.

Arthritis is frequently accompanied by joint pain. Joint pain is referred to as arthralgia.

There are many forms of arthritis (over 100 and growing). The forms range from those related to wear and tear of cartilage (such as osteoarthritis) to those associated with inflammation resulting from an overactive immune system (such as rheumatoid arthritis). Together, the many forms of arthritis make up the most common chronic illness in the United States.

The causes of arthritis depend on the form of arthritis. Causes include injury (leading to osteoarthritis), abnormal metabolism (such as gout and pseudogout), inheritance, infections, and unclear reasons (such as rheumatoid arthritis and systemic lupus erythematosus).

Arthritis is classified as one of the rheumatic diseases. These are conditions that are different individual illnesses, with differing features, treatments, complications, and prognosis. They are similar in that they have a tendency to affect the joints, muscles, ligaments, cartilage, tendons, and many have the potential to affect internal body areas.